| Protecting mitochondrial function during the process of freezing sperm |
| Paper ID : 1038-WDG2017 |
| Authors |
|
حمید عبدالرحیمی بارنجی * بارنج-کوی آزادگان-ونک۱۰- پلاک ۹ |
| Abstract |
| The purpose of this study was to evaluate the performance of mitochondria-targeted antioxidant in protecting mitochondrial function and improving sperm fertility. Mitochondria are attractive targets for the delivery of antioxidants, because they play a role in the production of ATP, cell signaling, calcium hemostasis, fertility, keratinization and sperm fertility. The change in the integrity and function of mitochondria means defect in the mitochondrial ultra-structural and/ or mitochondrial genome, transcription, reduction of the mitochondrial membrane potential, change in oxygen consumption with loss of sperm function. The lack of permeability of the mitochondrial membrane relative to the antioxidants causes the antioxidants to not be able to locate and neutralize the reactive oxygen species (ROS). mitochondria-targeted antioxidant based on their mechanism of action can be divided into four categories (uncoupling, conjugate antioxidants with triphenylphosphonium (TPP), SS peptides, and spin traps). The most important type of mitochondria-targeted antioxidant known as conjugate antioxidants are TPP, which are formed from an antioxidants component attached to TPP, and this cation causes several hundreds of antioxidants to accumulate in the mitochondria. The most important mitochondria-targeted antioxidant is SKQ, which plays a role in the ROS inhibition process, inhibits sperm motility and prologs its life span, and acts as a mitochondrial separator. |
| Keywords |
| mitochondria-targeted antioxidant, uncoupling, Infertility |
| Status: Abstract Accepted (Poster Presentation) |